Palladium-Catalyzed Stereoselective Construction of 1,3-Stereocenters Displaying Axial and Central Chirality via Asymmetric Alkylations

Palladium-Catalyzed Stereoselective Construction of 1,3-Stereocenters Displaying Axial and Central Chirality via Asymmetric Alkylations

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The concurrent construction of 1,3-stereocenters remains a challenge.Herein, we report the development of stereoselective union of a point chiral center with allenyl axial chirality MENO SUPPORT COMPLEX in 1,3-position by Pd-catalyzed asymmetric allenylic alkylation between racemic allenyl carbonates and indanone-derived β-ketoesters.Various target products bearing a broad range of functional groups were afforded Custom Shape Warm LED Night Light in high yield (up to 99%) with excellent enantioselectivities (up to 98% ee) and good diastereoselectivities (up to 13:1 dr).